Kalpana Kalpana (Editor)

DNA formamidopyrimidine glycosylase

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EC number
  
3.2.2.23

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
78783-53-6

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

DNA-formamidopyrimidine glycosylase (EC 3.2.2.23, Fapy-DNA glycosylase, deoxyribonucleate glycosidase, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase, formamidopyrimidine-DNA glycosylase, DNA-formamidopyrimidine glycosidase, Fpg protein) is an enzyme with systematic name DNA glycohydrolase (2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing). This enzyme catalyses the following chemical reaction

Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine

This enzyme participates in processes leading to recovery from mutagenesis and/or cell death by alkylating agents.

References

DNA-formamidopyrimidine glycosylase Wikipedia