Species Human Entrez 9787 | Human Mouse Ensembl ENSG00000126787 | |
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Aliases DLGAP5, DLG7, HURP, discs large homolog associated protein 5, DLG associated protein 5 External IDs MGI: 2183453 HomoloGene: 8840 GeneCards: DLGAP5 | ||
Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.
DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture. DGL7 is a part of Ran-dependent complex. Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase. Expression of DGL7 is found in cancer and stem cells.
References
DLGAP5 Wikipedia(Text) CC BY-SA