Entrez 81623 | Ensembl ENSG00000125788 | |
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Aliases DEFB126, C20orf8, DEFB-26, DEFB26, bA530N10.1, hBD-26, HBD26, defensin beta 126 External IDs HomoloGene: 49954 GeneCards: DEFB126 | ||
Function
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. The encoded protein is highly similar to an epididymal-specific secretory protein (ESP13.2) from cynomolgus monkey.
It has been suggested that a common variation in the DEFB126 gene generates abnormal mRNA and can somewhat impair fertility.
References
DEFB126 Wikipedia(Text) CC BY-SA