D nopaline dehydrogenase

In enzymology, a D-nopaline dehydrogenase (EC 1.5.1.19) is an enzyme that catalyzes the chemical reaction

N₂-(D-1,3-dicarboxypropyl)-L-arginine + NADP⁺ + H₂O ⇌ L-arginine + 2-oxoglutarate + NADPH + H⁺

The 3 substrates of this enzyme are N2-(D-1,3-dicarboxypropyl)-L-arginine, NADP⁺, and H₂O, whereas its 4 products are L-arginine, 2-oxoglutarate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming). Other names in common use include D-nopaline synthase, nopaline dehydrogenase, nopaline synthase, NOS, 2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase, and (L-arginine-forming). This enzyme participates in arginine and proline metabolism.