D lysopine dehydrogenase

In enzymology, a D-lysopine dehydrogenase (EC 1.5.1.16) is an enzyme that catalyzes the chemical reaction

N₂-(D-1-carboxyethyl)-L-lysine + NADP⁺ + H₂O ⇌ L-lysine + pyruvate + NADPH + H⁺

The 3 substrates of this enzyme are N2-(D-1-carboxyethyl)-L-lysine, NADP⁺, and H₂O, whereas its 4 products are L-lysine, pyruvate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming). Other names in common use include D-lysopine synthase, lysopine dehydrogenase, D(+)-lysopine dehydrogenase, 2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase, and (L-lysine-forming). This enzyme participates in lysine degradation.