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D alanine—alanyl poly(glycerolphosphate) ligase

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EC number
  
6.3.2.16

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
9046-58-6

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a D-alanine—alanyl-poly(glycerolphosphate) ligase (EC 6.3.2.16) is an enzyme that catalyzes the chemical reaction

ATP + D-alanine + alanyl-poly(glycerolphosphate) ADP + phosphate + D-alanyl-alanyl-poly(glycerolphosphate)

The 3 substrates of this enzyme are ATP, D-alanine, and alanyl-poly(glycerolphosphate), whereas its 3 products are ADP, phosphate, and D-alanyl-alanyl-poly(glycerolphosphate).

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming). Other names in common use include D-alanyl-alanyl-poly(glycerolphosphate) synthetase, D-alanine:membrane-acceptor ligase, D-alanylalanylpoly(phosphoglycerol) synthetase, D-alanyl-poly(phosphoglycerol) synthetase, and D-alanine-membrane acceptor-ligase. This enzyme participates in d-alanine metabolism.

References

D-alanine—alanyl-poly(glycerolphosphate) ligase Wikipedia