D'Amico or Di Amico is an Italian surname. Notable people with the surname include:
Antonio D'Amico (born 1959), Italian model and fashion designerAndrea D'Amico (football agent)Andrea D'Amico (footballer)Fat Tony (The Simpsons) (Anthony "Fat Tony" D'Amico), fictional character on The Simpsons animated seriesHank D'Amico (1915–65), American jazz clarinetistIlaria D'Amico (born 1974), Italian commentatorJackie 'Nose' D'Amico (born c.1937), American mobster and head of the Gambino crime familyJeff D'Amico (born 1975), American professional baseball playerJohn D'Amico (disambiguation), multiple peopleJoseph D'Amico (born 1955), former Bonanno crime family soldier and informantPasquale D'Amico, former Neapolitan Camorrista who became a pentito (Collaborator with Italian Justice)Rudy D'Amico (born 1940), American National Basketball Association scout, and former college and professional basketball coach who coached Maccabi Tel Aviv to the Euroleague ChampionshipTamela D'Amico, American singer, actress, and filmmakerSuso Cecchi d'Amico, Italian screenwriter