D'Onofrio (sometimes spelled Donofrio) is a surname of Italian origin. People bearing this name include the following:
Beverly Donofrio (b. 1950), American author
Denis D'Onofrio (b. 1989), Italian footballer
Dominique D'Onofrio (1953–2016), Italo-Belgian football coach
Elizabeth D'Onofrio (b. 1957), American film producer, actress, and acting coach; sister of Vincent D'Onofrio
Mark D'Onofrio (b. 1969), American former college football coach and former professional player
Nicola D'Onofrio (1943–1984), Italian Camillian monk
Vincent D'Onofrio (b. 1959), American actor; brother of Elizabeth D'Onofrio