D'Angelo is a surname. Notable people with the surname include:
Beverly D'Angelo, American actress
Frank D'Angelo, Canadian beverage industry entrepreneur
Gianna D'Angelo (1929–2013), American soprano
Ernesto Pérez d'Angelo (1932–2013), Chilean paleontologist
Josephine D'Angelo (1924–2013), American baseball player
Sharlee D'Angelo, bassist of Swedish melodic death metal band Arch Enemy