D'Amico or Di Amico is an Italian surname. Notable people with the surname include:
Antonio D'Amico (born 1959), Italian model and fashion designer
Andrea D'Amico (football agent)
Andrea D'Amico (footballer)
Fat Tony (The Simpsons) (Anthony "Fat Tony" D'Amico), fictional character on The Simpsons animated series
Hank D'Amico (1915–65), American jazz clarinetist
Ilaria D'Amico (born 1974), Italian commentator
Jackie 'Nose' D'Amico (born c.1937), American mobster and head of the Gambino crime family
Jeff D'Amico (born 1975), American professional baseball player
John D'Amico (disambiguation), multiple people
Joseph D'Amico (born 1955), former Bonanno crime family soldier and informant
Pasquale D'Amico, former Neapolitan Camorrista who became a pentito (Collaborator with Italian Justice)
Rudy D'Amico (born 1940), American National Basketball Association scout, and former college and professional basketball coach who coached Maccabi Tel Aviv to the Euroleague Championship
Tamela D'Amico, American singer, actress, and filmmaker
Suso Cecchi d'Amico, Italian screenwriter
