EC number 2.7.4.14 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 37278-21-0 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a cytidylate kinase (EC 2.7.4.14) is an enzyme that catalyzes the chemical reaction
ATP + (d)CMPThus, the two substrates of this enzyme are ATP and dCMP, whereas its two products are ADP and dCDP.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:CMP phosphotransferase. Other names in common use include: deoxycytidylate kinase, deoxycytidylate kinase, CMP kinase, CTP:CMP phosphotransferase, dCMP kinase, deoxycytidine monophosphokinase, UMP-CMP kinase, ATP:UMP-CMP phosphotransferase, and pyrimidine nucleoside monophosphate kinase. This enzyme participates in pyrimidine metabolism.
Structural studies
As of late 2007, 17 structures have been solved for this class of enzymes, with PDB accession codes 1CKE, 1KDO, 1KDP, 1KDR, 1KDT, 1Q3T, 1QF9, 1TEV, 1UKE, 2CMK, 2FEM, 2FEO, 2H92, 2UKD, 3UKD, 4UKD, and 5UKD.