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Cysteine dioxygenase

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Covid-19
EC number  1.13.11.20
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  37256-59-0
BRENDA  BRENDA entry
KEGG  KEGG entry
Cysteine dioxygenase

Cysteine dioxygenase (CDO, CAS number: 37256-59-0) is a mammalian non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen.

Cysteine sulfinic acid lies at a branch-point in cysteine catabolism, where it can follow two pathways resulting in the formation of taurine or sulfate. The cysteine sulfinic acid-dependent pathway of taurine metabolism follows the synthesis of hypotaurine (2-aminoethane sulfinate), which is subsequently oxidized to taurine. Also, cysteine sulfinate can undergo transamination to form β-sulfinylpyruvate, decomposing to form pyruvate and sulfite.

References

Cysteine dioxygenase Wikipedia


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