Kalpana Kalpana (Editor)

Cyclorphan

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CAS Number
  
4163-15-9

ChemSpider
  
4514407

ECHA InfoCard
  
100.021.825

Molar mass
  
297.434 g/mol

PubChem CID
  
5359966

ChEMBL
  
CHEMBL49269

Formula
  
C20H27NO

Density
  
1.19 g/cm³

Cyclorphan httpsuploadwikimediaorgwikipediacommonsthu

Cyclorphan is an opioid analgesic of the morphinan family that was never marketed. It acts as a μ-opioid receptor (MOR) weak partial agonist or antagonist, κ-opioid receptor (KOR) full agonist, and, to a much lesser extent, δ-opioid receptor (DOR) agonist (75-fold lower affinity relative to the KOR). The drug was first synthesized in 1964 by scientists at Research Corporation. In clinical trials, it had relatively long duration, good absorption, and provided strong pain relief but produced psychotomimetic effects via KOR activation, so its development was not continued.

References

Cyclorphan Wikipedia


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