Cuomo is a surname. Notable people with the surname include:
Cuomo family, the United States political family
Andrew Cuomo, the current governor of New York State, and son of Mario Cuomo
Chris Cuomo (b. 1970), journalist; son of Mario Cuomo
Margaret I. Cuomo, physician, radiologist, author, and philanthropist; daughter of Mario Cuomo
Mario Cuomo, former governor of New York State (1983–1995)
Rivers Cuomo, U.S. musician, of the group Weezer
Chris Cuomo (philosopher), U.S. philosopher
Donna Cuomo, U.S. politician
Douglas J. Cuomo, U.S. composer
Franco Cuomo, Italian journalist
Gennaro A. Cuomo (Jerry Cuomo), U.S. software engineer, IBM Fellow
George Michael Cuomo, U.S. author
James Cuomo, U.S. composer
Luigi Cuomo, Italian fencer
Nancy Cuomo, Italian singer
Nicola Cuomo, Italian professor, educator
Saint Conon the Elder (d. 275), also Cuomo the Elder, father of Saint Conon the Younger; from Iconium in Asia Minor
Saint Conon the Younger (d. 275), also Cuomo the Younger, son of Saint Conon the Elder; from Iconium in Asia Minor
Salvatore Cuomo, Italian celebrity chef
Sandro Cuomo, Italian fencer
Yolanda Cuomo, U.S. artist