Cuomo is a surname. Notable people with the surname include:
Cuomo family, the United States political familyAndrew Cuomo, the current governor of New York State, and son of Mario CuomoChris Cuomo (b. 1970), journalist; son of Mario CuomoMargaret I. Cuomo, physician, radiologist, author, and philanthropist; daughter of Mario CuomoMario Cuomo, former governor of New York State (1983–1995)Rivers Cuomo, U.S. musician, of the group WeezerChris Cuomo (philosopher), U.S. philosopherDonna Cuomo, U.S. politicianDouglas J. Cuomo, U.S. composerFranco Cuomo, Italian journalistGennaro A. Cuomo (Jerry Cuomo), U.S. software engineer, IBM FellowGeorge Michael Cuomo, U.S. authorJames Cuomo, U.S. composerLuigi Cuomo, Italian fencerNancy Cuomo, Italian singerNicola Cuomo, Italian professor, educatorSaint Conon the Elder (d. 275), also Cuomo the Elder, father of Saint Conon the Younger; from Iconium in Asia MinorSaint Conon the Younger (d. 275), also Cuomo the Younger, son of Saint Conon the Elder; from Iconium in Asia MinorSalvatore Cuomo, Italian celebrity chefSandro Cuomo, Italian fencerYolanda Cuomo, U.S. artist