Culpeper, Colepeper, or Culpepper is a surname. Notable people with the surname include:
The Barons Culpeper, including:Sir Thomas Culpeper, 3rd Baronet (1588–1651), English politicianThe Barons Colepeper, including:John Colepeper, 1st Baron Colepeper (d. 1660), English politician, Chancellor of the Exchequer 1643–1646Thomas Colepeper, 2nd Baron Colepeper (1635–1689), English colonial governor of VirginiaAlan Culpepper (b. 1972), American distance runner, married to Shayne CulpepperAllen Ross Culpepper (1944–1969), American army captain cited for "extraordinary heroism" in the Vietnam WarBobby Culpepper (1941–2015), American lawyer and politicianBrad Culpepper (b. 1969), American football playerDaunte Culpepper (b. 1977), American football playerJohn Culpeper (1366–1414), knight in the court of Henry VJohn Culpepper (1761–1841), U.S. Representative from North CarolinaMartyn Culpepper (fl. 1573–1599), English academic administrator at the University of OxfordMarvin T. Culpepper (1908–1970), member of the Louisiana House of RepresentativesNicholas Culpeper (1616–1654), English botanist, herbalist, physician, and astrologerRobert C. Culpepper (1873–1950), American politician and judgeShayne Culpepper (b. 1973), American middle distance athleteThomas Culpeper (1514–1541), courtier of Henry VIIIWilliam A. Culpepper (1916–2015), state court judge in LouisianaWilliam T. Culpepper, III (b. 1947), North Carolina General Assemblyman