Cullum is a surname. Notable people with the surname include:
Albert Cullum, American educator
Ben Cullum, British musician
George Washington Cullum, American Civil War general and Superintendent of the U.S. Military Academy
Jamie Cullum (born 1979), English pianist and songwriter
Jim Cullum, Jr., American cornetist and bandleader
John Cullum, American actor and singer
Kimberly and Kaitlin Cullum, American former child actors who are also sisters
Leo Cullum (1942–2010), American cartoonist, father of Kimberly and Kaitlin Cullum
Ridgwell Cullum (1867–1943), British writer of adventure novels
Robert B. Cullum, American businessman and civic leader from Dallas
Thomas Gery Cullum (1741–1831), medical doctor, botanist (abbrev. Cullum), and antiquary