Cruikshank is a surname and is a spelling variation of Cruickshank. Notable people with the surname include:
Brad Cruikshank (born 1979), Canadian ice hockey winger
Chester Cruikshank (1913–1970), American athlete
Dan Cruikshank (born 1949) architectural historian and broadcaster
George Cruikshank (1792–1878), English caricaturist
Holly Cruikshank (born 1973), American dancer
Isaac Cruikshank (1756–1811), Scottish painter and caricaturist
Isaac Robert Cruikshank (1789–1856), caricaturist, illustrator, and portrait miniaturist
Lucas Cruikshank (born 1993), web producer and creator of Fred, a web-based show on YouTube
Marcus Henderson Cruikshank (1826–1881), Confederate States of America politician
Robert Edward Cruickshank (1888–1961), Anglo-Canadian soldier, recipient of the Victoria Cross
Sally Cruikshank (born 1949), American cartoonist and animator
Thomas H. Cruikshank, former chairman and CEO of Halliburton Energy Services
William Cruikshank (disambiguation), several people
Ed Cruikshank (born 1965) English furniture designer and artist based in Queenstown NZ
