Neha Patil (Editor)

Crc (protein)

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Covid-19
Symbol  Crc
CDD  cd08372
PDB  RCSB PDB; PDBe; PDBj
Pfam  PF03372
Pfam  structures
PDBsum  structure summary
Crc (protein)

The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria. Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted. Crc-mediated regulation impact processes such as biofilm formation, virulence and antibiotic susceptibility.

Interactions

Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation.

References

Crc (protein) Wikipedia


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