Cowie is a surname. Notable people with the surname include:
Chris Cowie, Scottish DJ and producer
Colin Cowie, lifestyle guru
Don Cowie (footballer), association football player
George Cowie, Scottish football player
George Cowie (Wisconsin), American politician
Helen Cowie, Professor of Health and Social Care at University of Sussex
Jack Cowie, New Zealand cricketer
James Cowie (Australian settler), mayor of Geelong, Victoria
James Cowie (artist), Scottish painter
Jimmy Cowie, Scottish footballer
Lennox Cowie, Scottish astronomer
Peter Cowie, English film historian
Richard Kylea Cowie, British musician better known as Wiley (rapper)
Thomas Jefferson Cowie, US Navy rear admiral
Sir Tom Cowie, English businessman