Symbol CRF-BP InterPro IPR008435 PDB RCSB PDB; PDBe; PDBj | Pfam PF05428 Pfam structures PDBsum structure summary | |
Corticotropin-releasing factor binding protein family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP).
Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development.
Corticotropin-releasing factor binding protein (CRH-BP) is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development.