Cooley is a surname of Anglo-Saxon and Irish origin.
Charles Cooley (1864–1929), American sociologist
Chelsea Cooley (born 1983), Miss USA 2005
Chris Cooley (American football) (born 1982), American professional football player
David P. Cooley (1960–2009), American test pilot
Dennis Cooley (born 1944), Canadian poet, professor at the University of Manitoba
Denton Cooley (1920−2016), American physician and heart surgeon
Ed Cooley (born 1969), basketball coach
Haskell Cooley, member of American southern gospel quartet The Cathedrals
Horace S. Cooley (1806-1850), American politician
James Cooley (born 1926), American mathematician, developer of the Cooley–Tukey fast Fourier transform
Joe Cooley (1924–1973), Irish accordionist
John K. Cooley (1927–2008), American journalist and author, specializing in terrorism and the Middle East
Lou Cooley (dates unknown), American 19th-century gunfighter, friend of Wyatt Earp at the time of the Gunfight at the O.K. Corral (1881)
Mason Cooley (1927–2002), American aphorist
Mike Cooley (engineer) (born 1934), Irish-born engineer and workplace activist
Mike Cooley (football coach) (c. 1920–1988), US football coach
Mike Cooley (born 1966), American guitarist/singer/lyricist, and co-founder of the rock/alt country band, Drive-By Truckers
Rusty Cooley, American guitarist
Ryan Cooley (born 1988), Canadian television actor
Spade Cooley (1910–1969), American western swing musician, murdered his wife
Stephen Cooley (born 1947), American prosecutor for Los Angeles County
Thomas B. Cooley (1871–1945), American Pediatrician, first described ß-Thalassemia
Thomas F. Cooley, American professor of economics at the New York University Stern School of Business
Thomas M. Cooley (1824–1898), American jurist, Chief Justice of the Michigan Supreme Court
Tonya Cooley (born 1980), reality television personality
Troy Cooley (born 1965), cricketer for the Tasmanian Tigers
Wes Cooley (born 1932), American politician, congressman from Oregon
Wes Cooley (motorcyclist) (born 1956), American motorcycle racer
William Cooley (1783–1863), Florida Pioneer
William Desborough Cooley (1795?–1883), Irish geographer
Winnifred Harper Cooley (1874—1967), American feminist author