Combs is a surname. Notable people with the surname include:
Sports:
Beth Combs, American basketball coach
Earle Combs (1899-1976), American center fielder and Baseball Hall of Fame member
Glen Combs (born 1946), American basketball player
Merl Combs (1919-1981), a shortstop in Major League Baseball from 1947-1952
Pat Combs (born 1966), a Philadelphia Phillies pitcher from 1989-1992
Television:
Jeffrey Combs (born 1954), American character actor
Ray Combs (1956-1996), American television game show host and stand-up comedian
Holly Marie Combs (born 1973), American actress
Other:
Allan Combs (born 1942), consciousness researcher and neuropsychologist
John Combs, Manitoba judge
Lewis Combs (1895 – 1996), United States Admiral
Rodney Combs (born 1950), American NASCAR driver
Sean Combs (born 1969), American record producer, CEO, clothing designer, actor, and rapper known as Diddy
Susan L Combs, an American businesswoman