Colombo is an Italian surname. Notable people with the surname include:
Cristoforo Colombo, the Italian language name of Italian explorer Christopher ColumbusEmilio Colombo, Prime Minister of Italy 1970–1972 and subsequently lifetime SenatorGherardo Colombo (born 1946), Italian magistrateGioacchino Colombo, Italian automobile engine designerGiovanni Colombo (1902–1992), Cardinal and Archbishop of MilanGiuseppe Colombo "Bepi", Italian mathematicianJoe Cesare Colombo (1930–1971), Italian industrial designerJürgen Colombo, German track cyclistLuca Colombo, Italian racing cyclistMaría Colombo, Argentine field hockey playerRealdo Colombo, anatomist and surgeon from the 16th centuryRoberto Colombo, former Grand Prix motorcycle racer.Umberto Colombo (1927–2006), Italian scientistColombo crime family of New York, its namesake Joseph Colombo