Coble is a surname. Notable people with the surname include:
Arthur Byron Coble (1878–1966), American mathematician
Bob Coble (born 1953), former mayor of Columbia, South Carolina, USA
Dave Coble (1912–1971), American baseball player
Eric Coble, playwright and screenwriter
Howard Coble (1931–2015), U.S. Representative from North Carolina
Paul Coble (born 1953), North Carolina politician, former mayor of Raleigh