Clune is a surname. Notable people with the surname include:
Conor Clune (1893–1920), Irish Bloody Sunday casualtyDeirdre Clune (born 1959), Irish politicianDon Clune (born 1952), American football playerFrank Clune (1893–1971), Australian writerHenry W. Clune (1890–1995), American journalist and novelistJackie Clune (born 1965), British entertainer and writerJohn J. Clune (1932–1992), former Director of Athletics at the United States Air Force AcademyPatrick Clune (1865–1935), first Archbishop of the Roman Catholic archdiocese of Perth, Western AustraliaRichard Clune (born 1987), Canadian ice hockey playerWally Clune (born 1931), Canadian retired ice hockey playerMichael W. Clune (born 1976), American writer and critic