Clotworthy Upton, 1st Baron Templetown (14 March 1721 – 16 April 1785) was an Anglo-Irish courtier and peer.
He was the youngest son of Lt Col John Upton, of Castle Upton, County Antrim, by his wife Mary Upton, only daughter of Dr Francis Upton. He served as Clerk Comptroller to Augusta, Dowager Princess of Wales between 1761 and 1772. In 1768 he succeeded to the family estates following the deaths of both of his brothers. On 3 August 1776 he was created Baron Templetown, of Templetown in the County of Antrim in the Peerage of Ireland, and assumed his seat in the Irish House of Lords.
He married Elizabeth Boughton, a Lady of the Bedchamber to the Princess Amelia, on 25 August 1769. He was succeeded in his title by his eldest son, John Upton, who was created Viscount Templetown in 1806.