Clarke is a given name. Notable people with the name include:
Clarke Abel (c. 1789–1826), British surgeon and naturalistClarke Carlisle (born 1979), English footballerClarke Dermody (born 1980), New Zealand rugby union footballerClarke Fraser (born 1920), Canadian medical geneticistClarke Hinkle (1909-1988), American National Football League playerClarke Hogan (born 1969), American politicianClarke Lewis (1840–1896), United States Representative from MississippiClarke MacArthur (born 1985), Canadian National Hockey League playerClarke Peters (born 1952), American actor, singer, writer and directorClarke Reed (born 1928), American politicianClarke Scholes (1930-2010), American swimmer and Olympic gold medalistClarke Wilm (born 1976), Canadian hockey player