Clarke is a given name. Notable people with the name include:
Clarke Abel (c. 1789–1826), British surgeon and naturalist
Clarke Carlisle (born 1979), English footballer
Clarke Dermody (born 1980), New Zealand rugby union footballer
Clarke Fraser (born 1920), Canadian medical geneticist
Clarke Hinkle (1909-1988), American National Football League player
Clarke Hogan (born 1969), American politician
Clarke Lewis (1840–1896), United States Representative from Mississippi
Clarke MacArthur (born 1985), Canadian National Hockey League player
Clarke Peters (born 1952), American actor, singer, writer and director
Clarke Reed (born 1928), American politician
Clarke Scholes (1930-2010), American swimmer and Olympic gold medalist
Clarke Wilm (born 1976), Canadian hockey player
