EC number 4.1.3.6 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9012-83-3 BRENDA BRENDA entry KEGG KEGG entry | |
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In enzymology, a citrate (pro-3S)-lyase (EC 4.1.3.6) is an enzyme that catalyzes the chemical reaction
Hence, this enzyme has one substrate, citrate, and two products, acetate and oxaloacetate.
This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate). Other names in common use include citrase, citratase, citritase, citridesmolase, citrate aldolase, citric aldolase, citrate lyase, citrate oxaloacetate-lyase, and citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]. This enzyme participates in citrate cycle and two-component system - general.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1U5H, 1U5V, 1Z6K, and 2HJ0.