Chronic vesiculobullous hand eczema presents with lesions that may be hyperkeratotic, scaling, and fissures, and the "dyshidrosiform" pattern may be recognized only during exacerbations. Females outnumber males by 3:1, and there is a tendency for the pruritic 1- to 2-mm vesicles to be most pronounced at the sides of the fingers.
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Chronic vesiculobullous hand eczema Wikipedia(Text) CC BY-SA