Chromosome 11 (human)

Updated on Jan 07, 2024

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Length (bp) 135,086,622 bp Type Autosome RefSeq NC_000011		No. of genes 2,920 2,893 Centromere position Submetacentric GenBank CM000673

Chromosome 11 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome. Chromosome 11 spans about 135 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies. In January 2017, two estimates differed insignificantly (0.3%), with one estimate giving 2,920 genes, and the other estimate giving 2,893 genes.

At 21.5 genes per megabase, Chromosome 11 is one of the most gene-rich, and disease-rich, chromosomes in the human genome.

More than 40% of the 856 olfactory receptor genes in the human genome are located in 28 single-gene, and multi-gene, clusters along this chromosome.

Genes

The following are some of the genes located on chromosome 11:

ACAT1: acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)

ACRV1: encoding protein Acrosomal protein SP-10

AMPD3: encoding enzyme AMP deaminase 3

APLNR: Apelin receptor (APJ receptor)

API5: encoding protein Apoptosis inhibitor 5

APOA4: apolipoprotein A-IV

ASRGL1: encoding enzyme L-asparaginase

ATM: ataxia telangiectasia mutated (includes complementation groups A, C and D)

B3GNT1: encoding enzyme N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

BDNF: secretes BDNF, a member of the Neurotrophin family of proteins

C11orf1: encoding protein

C11orf16: encoding protein Uncharacterized protein C11orf16

C11orf49: encoding protein UPF0705 protein C11orf49

C11orf54: encoding protein Ester hydrolase C11orf54

C11orf86: encoding protein Uncharacterized protein C11orf86

C1QTNF5: encoding protein C1q and tumor necrosis factor related protein 5

CCL9: Chemokine (C-C motif) ligand 9

CD81

CPT1A: carnitine palmitoyltransferase 1A (liver)

DHCR7: 7-dehydrocholesterol reductase

HBB: hemoglobin, beta

HMBS: hydroxymethylbilane VIIA

INS: insulin gene

MMP7: Matrix metalloproteinases (MMP family)

MEN1: Multiple endocrine neoplasia type 1

NRGN

PAX6

PTS: 6-pyruvoyltetrahydropterin synthase

RPL27A: encoding protein 60S ribosomal protein L27a

RPL36A: encoding protein 60S ribosomal protein L36a

SAA1: serum amyloid A1

SBF2: SET binding factor 2

SMPD1: sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)

TECTA: tectorin alpha (nonsyndromic deafness)

TH: tyrosine hydroxylase

USH1C: Usher syndrome 1C (autosomal recessive, severe)

WT1: Wilms tumor protein

RAG1/RAG2: recombination activating genes

Diseases and disorders

The following diseases and disorders are some of those related to genes on chromosome 11:

autism (neurexin 1)

annidraedea

acute intermittent porphyria

albinism

ataxia-telangiectasia

Beckwith-Wiedemann syndrome

Best's disease

beta-ketothiolase deficiency

beta thalassemia

bladder cancer

breast cancer

carnitine palmitoyltransferase I deficiency

Charcot-Marie-Tooth disease

Charcot-Marie-Tooth disease, type 4

Cystic Fibrosis

Depression

Denys-Drash syndrome

familial Mediterranean fever

Hereditary angioedema OMIM: 106100

Jacobsen syndrome

Jervell and Lange-Nielsen syndrome

Mantle cell lymphoma (t11;14)

Meckel syndrome

methemoglobinemia, beta-globin type

Mixed Lineage Leukemia

multiple endocrine neoplasia type 1

Hereditary Multiple Exostoses

Niemann-Pick disease

nonsyndromic deafness

nonsyndromic deafness, autosomal dominant

nonsyndromic deafness, autosomal recessive

porphyria

Potocki-Shaffer Syndrome

Romano-Ward syndrome

Sickle cell anemia

Smith-Lemli-Opitz syndrome

tetrahydrobiopterin deficiency

Usher syndrome

Usher syndrome type I

WAGR syndrome

Wilms' tumor

References

Chromosome 11 (human) Wikipedia

(Text) CC BY-SA

Contents

Genes

Diseases and disorders

References