Christodoulou (Greek: Χριστοδούλου) is a surname of Greek origin, the genitive form of the first name Christodoulos (Greek: Χριστόδουλος, "Servant of Christ").
Adam Christodoulou, British racing driver
Anastasios Christodoulou, Secretary General of the Association of Commonwealth Universities 1980 – 1996, and Foundation Secretary of the Open University
Andreas Christodoulou, Cypriot football midfielder
Christodoulos Christodoulou, Cypriot economist, lawyer and politician
Christopher Christodoulou, a musician
Christos Christodoulou, retired Greek professional basketball player
Demetrios Christodoulou, a Greek mathematician-physicist
Evangelia Christodoulou, winner of a bronze medal for Greece in the Rhythmic section at the 2000 Summer Olympics
Fanis Christodoulou, retired Greek professional basketball player
Georgios Christodoulou, international footballer for Cyprus
John Christodoulou, Cyprus-born British billionaire property developer
Jon Christos (born John Christodoulou), English singer, pianist, arranger, conductor and radio personality
Maria Christodoulou, Greek former synchronized Olympic swimmer
Marios Christodoulou, Cypriot football midfielder
Nikos Christodoulou, Greek conductor and composer
Nikolaos Christodoulou, Greek general
Pambos Christodoulou, Cypriot football manager
Petros Christodoulou, a Greek economist and banker
Riki Christodoulou, British racing driver
Stanley Christodoulou, international South African boxing referee