Cholesterol 5,6 oxide hydrolase

Updated on Nov 20, 2024

Edit

Comment

EC number 3.3.2.11 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

Cholesterol-5,6-oxide hydrolase (EC 3.3.2.11, cholesterol-epoxide hydrolase, ChEH) is an enzyme with systematic name 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase. This enzyme catalyses the following chemical reaction

(1) 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H₂O ⇌ 5alpha-cholestane-3beta,5alpha,6beta-triol(2) 5,6beta-epoxy-5beta-cholestan-3beta-ol + H₂O ⇌ 5alpha-cholestane-3beta,5alpha,6beta-triol

The enzyme works equally well with either epoxide as substrate.

References

Cholesterol-5,6-oxide hydrolase Wikipedia

(Text) CC BY-SA