Chloroformate

Chloroformates are a class of chemical compounds which are esters of chloroformic acid. They are widely used as reagents in organic chemistry. For example, benzyl chloroformate is used to introduce the Cbz protecting group and fluorenylmethyloxycarbonyl chloride is used to introduce the FMOC protecting group. They are gaining popularity in the field of chromatography as versatile derivatization agents. They enable relatively simple transformation of large array of metabolites (aminoacids, amines, carboxylic acids, phenols) for analysis by gas chromatography / mass spectrometry.