Harman Patil (Editor)

Chlordecone reductase

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EC number
  
1.1.1.225

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
102484-73-1

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction

chlordecone alcohol + NADP+ chlordecone + NADPH + H+

Thus, the two substrates of this enzyme are chlordecone alcohol and NADP+, whereas its 3 products are chlordecone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. This enzyme is also called CDR.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FVL.

References

Chlordecone reductase Wikipedia