Chambliss is a surname. Notable people with the surname include:
John R. Chambliss (1833–1864), American soldier
John R. Chambliss, Sr. (1809–1875), American politician
Chris Chambliss (born 1948), American baseball player
Saxby Chambliss (born 1948), American politician, Senior Senator from Georgia
Kirby Chambliss (born 1959), American flier
Robert Edward Chambliss (1904–1985), American Domestic Terrorist
William Chambliss (1933–2014), American criminologist and sociologist
