Chafin is a surname. Notable people with the surname include:
Andrew Chafin (born 1990), American Major League Baseball pitcher
Ben Chafin (born 1960), American politician and lawyer
Don Chafin (1887–1954), American sheriff and a commander in the 1921 Battle of Blair Mountain
Eugene W. Chafin (1852–1920), appointed to the bar of the Supreme Court of the United States and the Prohibition Party candidate for President of the US in the 1908 and 1912 elections
Truman Chafin (born 1945), former member of the West Virginia Senate
