EC number 1.1.99.18 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 54576-85-1 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a cellobiose dehydrogenase (acceptor) (EC 1.1.99.18) is an enzyme that catalyzes the chemical reaction
cellobiose + acceptorThus, the two substrates of this enzyme are cellobiose and acceptor, whereas its two products are cellobiono-1,5-lactone and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is cellobiose:acceptor 1-oxidoreductase. Other names in common use include cellobiose dehydrogenase, cellobiose oxidoreductase, Phanerochaete chrysosporium cellobiose oxidoreductase, CBOR, cellobiose oxidase, cellobiose:oxygen 1-oxidoreductase, CDH, and cellobiose:(acceptor) 1-oxidoreductase. It employs sometimes one cofactor, FAD, but in most cases both a heme and a FAD located in separate domains. It makes the enzyme to one of the more complex extracellular oxidoreductases. It is produced by wood degrading organisms.
Structural studies
To date, structures of the separated flavin and heme containing domains were reported (PDB accession codes 1NAA and 1PL3). In 2015, full-length structures of the enzyme were resolved (accession codes 4QI6 and 4QI7).