Girish Mahajan

Celastrol

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Celastrol (tripterine) is a chemical compound isolated from the root extracts of Tripterygium wilfordii (Thunder god vine) and Celastrus regelii. Celastrol is a pentacyclic triterpenoid and belongs to the family of quinone methides.

In in vitro and in vivo animal experiments, celastrol exhibits antioxidant, anti-inflammatory, anticancer, and insecticidal activities. It has been shown to have obesity-controlling effects in mice. Celastrol has also shown to possess (by inhibition of NF-κB in the hypothalamus) anti-diabetic effects on diabetic nephropathy and improve whole-body insulin resistance

References

Celastrol Wikipedia


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