MedlinePlus a601206 Molar mass 423.466 g/mol | Legal status US: ℞-only CAS ID 21593-23-7 | |
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AHFS/Drugs.com International Drug Names Pregnancycategory US: B (No risk in non-human studies) ATC code J01DB08 (WHO) QG51AA05 (WHO) QJ51DB08 (WHO) | ||
Cefapirin (INN, also spelled cephapirin) is an injectable, first-generation cephalosporin antibiotic. It is marketed under the trade name Cefadyl. Production for use in humans has been discontinued in the United States.
It also has a role in veterinary medicine as Metricure, an intrauterine preparation, and combined with prednisolone in Mastiplan, an intramammary preparation. Both are licensed in cattle.
Synthesis
In one of the syntheses, 7-aminocephalosporanic acid (7-ACA) is reacted with bromoacetyl chloride to give the amide. The halo group is then displaced by 4-thiopyridine.
References
Cefapirin Wikipedia(Text) CC BY-SA