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The Catholic Church in São Tomé and Príncipe is part of the Catholic Church, under the spiritual leadership of the Pope and Roman Curia in Rome and forms the largest religion in the country. A majority of the residents São Tomé and Príncipe adhere to Roman Catholicism.
In 2005, about 118,000 (88%) residents of São Tome and Principe were members of the Catholic Church. The country consists of a single diocese, Roman Catholic Diocese of São Tomé and Príncipe, which has Manuel António Mendes dos Santos as bishop since 2006. The bishop is a member of the Episcopal Conference of Angola and São Tomé whose president of the Episcopal Conference is Gabriel Mbilingi, bishop of Lubango (Angola). Furthermore, one member of the Inter Regional Meeting of Bishops of Southern Africa and Symposium of Episcopal Conferences of Africa and Madagascar.
The Nuncio of São Tome and Principe is Archbishop Novatus Rugambwa, which also Nuncio for Angola. The main Catholic church in the country is the Sé Catedral de Nossa Senhora da Graça de São Tomé.