Castile or Castille is a surname. Notable people with the surname include:
Brooke Castile (born 1986), American pairs figure skater
Christopher Castile (born 1980), American actor
L. J. Castile (born 1987), American football player
Simeon Castille (born 1985), NFL cornerback
Hadley Castille (born 1933), Cajun fiddler
Philando Castile (1983-2016), American man fatally shot by a police officer in St. Anthony, Minnesota