Castiglioni is a surname, and may refer to:
Achille Castiglioni (1918-2002), Italian industrial designer
Piero Castiglioni, Italian Lighting designer
Consuelo Castiglioni, b. 1959, Chilean-Italian fashion designer and founder of the house of Marni
Livio Castiglioni, Italian industrial designer
Pier Giacomo Castiglioni (1913-1968), Italian industrial designer
Giannino Castiglioni (1884-1971), Italian Artist, Sculptor and Medallist
Francesco Saverio Castiglioni (1761-1830), Pope Pius VIII
Goffredo da Castigline / Godfrey Castiglioni (died 1241), Pope Celestine IV
St. Buono Castiglioni (818-822)
St. Honoratus Castiglioni (568-572)
Luis Alberto Castiglioni Soria, former vice president of Paraguay
Camillo Castiglioni (1879-1961), Austrian financier and banker
Niccolò Castiglioni (1932-1996), Italian composer and pianist
Arturo Castiglioni (1874-1952), Italian-American medical historian