Castellini is an Italian surname. Notable people with the surname include:
Antonio Castellini (1951–1976), Italian boxer
Bob Castellini, American businessman
Claudio Castellini (born 1966), Italian comics artist
Giacomo Castellini, Italian Baroque painter
Luciano Castellini (born 1945), Italian footballer and manager
Marcello Castellini (born 1973), Italian footballer
Miguel Angel Castellini (born 1947), Argentine boxer
Paolo Castellini (born 1979), Italian footballer
Raffaelle Castellini (died 1864), Italian artist
