Cassirer is a German surname. Notable people with the surname include:
Richard Cassirer (1868–1925), German neurologist
Paul Cassirer (1871–1926), German art dealer and editor
Bruno Cassirer (1872–1941), German publisher and gallery owner in Berlin
Ernst Cassirer (1874–1945), German-Jewish philosopher
Edith Geheeb (1885–1982)
Fritz Cassirer (1871–1926), German conductor
Heinz Cassirer (1903–1979), German philosopher
Wilfred Cass, born Wolfgang Cassirer (born 1924), Founder of Cass Sculpture Foundation