The twenty-first season of the Case Closed anime was directed by Koujin Ochi and Yasuichiro Yamamoto and produced by TMS Entertainment and Yomiuri Telecasting Corporation. The series is based on Gosho Aoyama's Case Closed manga series. In Japan, the series is titled Detective Conan (名探偵コナン, Meitantei Conan) but was changed due to legal issues with the title Detective Conan. The series focuses on the adventures of teenage detective Shinichi Kudo who was turned into a child by a poison called APTX 4869, but continues working as a detective under the alias Conan Edogawa.
The episodes use five pieces of theme music: two opening and three ending themes. The first opening theme is "Miss Mystery" by Breakerz up until episode 666. The second opening theme is Kimi no Namida ni Kon'nani Koishiteru (君の涙にこんなに恋してる?, lit. So Much Love With Your Tears) by Natsuiro starting from episode 667. The first ending theme is Kanashimi hodo Kyō no Yūhi Kirei dane (悲しみほど 今日の夕陽きれいだね?, lit. "Compared With the Sadness, Today's Sunset Is More Beautiful") by grram and is used up to episode 653. The second ending theme is "Overwrite" (オーバーライト, Ōbāraito), and by Breakerz between episode 654 and 666. The third ending theme is Koi ni Koi Shite (恋に恋して?, lit. "In Love With Love") by Mai Kuraki starting from episode 667.
The season aired between February 18, 2012 and December 15, 2012 on Nippon Television Network System in Japan. As of October 2013, all nine volumes have been released.