The fifteenth season of the Case Closed anime was directed by Kenji Kodama and Yasuichiro Yamamoto and produced by TMS Entertainment and Yomiuri Telecasting Corporation. The series is based on Gosho Aoyama's Case Closed manga series. In Japan, the series is titled Detective Conan (名探偵コナン, Meitantei Conan) but was changed due to legal issues with the title Detective Conan. The episodes' plot follows Conan Edogawa's daily adventures.
The episodes use six pieces of theme music: three opening themes and three ending themes. The first opening theme is "Shōdō" (衝動?, lit. "Impulse") by B'z until episode 437. The second opening theme is "100 mo no Tobira" (100もの扉?, lit. "100 Doors") by Rina Aiuchi and U-ka Saegusa in dB until episode 456. The third opening theme is "Kumo ni Notte" (雲に乗って?, lit. "Ride on a Cloud") by U-ka Saegusa in dB for the rest of the season. The first ending theme is "Kanashii Hodo Anata ga Suki" (悲しいほど 貴方が好き?, lit. "I love you as much as I'm sad") by Zard until episode 437. The second ending theme is "Mou Kimi dake wo Hanashitari wa Shinai" (もう君だけを離したりはしない?, lit. "I won't let you go anymore") by Aya Kamiki until episode 458. The third ending theme is "Shiroi Yuki" (白い雪?, lit. "White Snow") by Mai Kuraki for the rest of the season.
The season initially ran from January 23, 2006 through February 19, 2007 on Nippon Television Network System in Japan. Episodes 427 to 465 were later collected into ten DVD compilations by Shogakukan. They were released between December 22, 2006 and September 28, 2007 in Japan.