Casali is an Italian surname. Notable people with the surname include:
Andrea Casali (1705–1784), Italian painter
Charles Casali (1923–2014), Swiss footballer
Curt Casali (born 1988), American baseball player
Giovanni di Casali, Italian mathematician and theologian
Giovanni Battista Casali (1715–1792), Italian musician
Kim Casali (1941–1997), New Zealand cartoonist
Casali brothers, Dario and Milo Casali