Casale is an Italian surname. Notable people with the surname include:
Gerald Casale, musician
Giovanni Casale (born 1980), Italian judoka
Giuseppe Casale (born 1923), Italian bishop
Joseph Casale (born 1950), Italian born entrepreneur
Luigi Casale industrial chemist
Mark Casale, American football player
Nathalie Alonso Casale (born 1970), Dutch filmmaker
Rossana Casale (born 1959), Italian singer
Stefano Casale (born 1971), Italian footballer
Ubertino da Casale (1259–1329), Italian theologian
