Rahul Sharma

Capreomycin

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Trade names  Capastat
MedlinePlus  a682860
Routes of administration  intramuscular
Molar mass  668.706 g/mol
AHFS/Drugs.com  Monograph
Pregnancy category  C
ATC code  J04AB30 (WHO)
CAS ID  11003-38-6
Capreomycin

Capreomycin is an antibiotic which is given in combination with other antibiotics for the treatment of tuberculosis. Specifically it is a second line treatment used for active drug resistant tuberculosis. It is given by injection into a vein or muscle.

Common side effects include kidney problems, hearing problems, poor balance, and pain at the site of injection. Other side effects include paralysis resulting in the inability to breath. It is not recommended with streptomycin or other medications that may damage the auditory vestibular nerve. It is not recommended during pregnancy as it may cause kidney or hearing problems in the baby. Capreomycin is commonly grouped with the aminoglycoside family of medications. How it works is unclear.

Capreomycin was discovered from Streptomyces capreolus in 1960. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 6.25 to 8.98 USD a dose.

Spectrum of susceptibility

Capreomycin is most commonly used to treat Mycobacterium tuberculosis infections. Mycobacterium tuberculosis growth has been found to be inhibited at a concentration of 2.5 μg/mL.

References

Capreomycin Wikipedia


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